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Lupus Dictionary A-C


 A-C | D-N | O-Z

Acute Of short duration & coming on suddenly
Adrenal glands Small organs, located above the kidney, that produce many hormones, including corticosteroids & epinephrine
Albumin A protein that circulates in the blood & carries materials to cells
Albuminuria A protein in urine
Alopecia Hair loss
Anaemia A condition resulting from low red blood cell counts
Analgesic A drug that alleviates pain (painkiller)
Antibodies Special protein substances made by the body's white cells for defense against bacteria & other foreign substances
Anticardiolipin antibody An antiphospholipid antibody
Anti-DNA Antibodies to DNA;seen in half of those with systemic lupus & implies serious disease
Anti-ENA Old term for extractable nuclear antibodies, which largely consist of anti-SM & anti-RNP antibodies
Antigen A substance that stimulates antibody formation;in lupus, this can be a foreign substance or a product of the patient's own body
Anti-inflammatory An agent that counteracts or suppresses inflammation
Antimalarials Drugs originally used to treat malaria that are helpful for lupus
Antinuclear antibodies(ANA) Proteins in the blood that react with the nuclei of cells. Seen in 96% of those with SLE, in 5% of healthy individuals, & in most patients with autoimmune diseases
A titer of 1:80 or above is usually considered positive
Antiphospholipid antibody Antibodies to a constituent of cell membranes seen in one-third of those with SLE. In the presence of a co-factor, these antibodies can altert clotting & lead to strokes, blood clots, miscarriages, & low platelet counts. Also detected as the lupus anticoagulent
Anti-RNP Antibody to ribonucleoprotein. Seen in SLE & mixed connective tissue disease
Anti-Sm Anti-Smith antibody; found only in lupus
Anti-SSA or the Ro antibody, is associated with Sjogren's syndrome, sun sensitivity, neonatal lupus, & congenital heartblock
Anti-SSB or the La antibody, is almpost always seen with anti-SSA
Apheresis Process of removing blood or some component of it from the body.
Apoptosis Programmed cell death
Arthralgia Pain in a joint
Arthritis Inflammation of a joint
Aseptic meningitis Inflammation of the lining of the brain (meninges) that is not due to any infectious agent
Autoantibody An antibody to one's own tissues or cells
Autoimmunity Allergy to one's own tissues
B lymphocyte or B cell A white blood cell that makes antibodies
Basophils Make up less than 1% of white blood cells. These specialised cells combat parasitic or fungal invasion, & also play a roll in allergy. Normal range = up to 0.15
Biopsy Removal of a bit of tissue for examination under the microscope
Bullous lupus Produces fluid-filled blisters or a rash similar to that of chickenpox.
Blood urea nitrogen (BUN) A product of protein metabolism. When the kidneys fail, the BUN levels rise, as do the levels of uric acid
Bursa A sac of synovial fluid between tendons, muscles, & bones that promotes easier movement
Butterfly rash Reddish facial eruption over the bridge of nose & cheeks, resembling a butterfly in flight. Also known as Malar rash.
Cardiac tamponade Accumulation of fluid around the heart.
Cartilage Tissue material covering bone
Chillblains A term used to describe cold-blisters on or inflammation of the fingers, toes or ears
Chromosomes Rod-shaped bodies in nucleus of cells containing the genes
Chronic Persisting over a long period of time
CNS Central nervous system
Cognition Awareness; ability to think methodically
Connective tissue The 'glue' that holds muscles, skin & joints together
Complement A group of proteins that, when activated, promote & are consumed during inflammation.
CH50 (Complement, total hemolytic), Normal range=52-128 CAE units
Complement C4, Normal range = 30-60 mg/dl
Complement C3, Normal range = 83-240 mg/dl
Complete blood count(CBC) A blood test that measures the amount of red blood cells, white blood cells, & platelets in the body
Corticosteroid Any natural anti-inflammatory hormone made by the adrenal cortex; can also be made synthetically
Cortisone A synthetic corticosteroid
Creatinine A waste product of creatine metabolism. There are high levels of creatinine in the blood when the kidneys are not functioning properly
CREST syndrome A form of limited sclerodoma characterised by Calcium deposits under the skin, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly or tight skin, & a rash called Telangiectasia
Crossover syndrome An autoimmune process that has features of more than one rheumatic disease(e.g. lupus & scleroderma)
CRP (C-reactive protein) A blood protein. Raised levels are found in inflammation such as infections
Cutaneous Relating to the skin
Cytokine A group of chemicals that signal cells to perform certain actions

 A-C | D-N | O-Z

 
 

 

 
 

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